Research in Nuclear Medicine using phantom able to simulate thorasic movements
Preclinical research in diagnostic nuclear medicine for the optimization of myocardial perfusion imaging will be presented.
For this purpose, an anthropomorphic phantom assembly was developed and utilized in SPECT/CT imaging. The physical phantom assembly simulates three body-types and thoracic motions such as ECG heart beating, lungs breathing and lungs-heart cranio-caudal motion during normal and deep respiration, in time-interval of 10ms. Radiopharmaceuticals can be injected, and cardiac defects of various sizes can be positioned, within the myocardial walls of the left ventricle.
SPECT/CT images were acquired for phantoms with and without small and large cardiac defects during normal and deep breathing, and also at four static respiratory phases. Acquisitions were reconstructed with and without AC, and with misalignment of transmission and emission scans. A quantitative analysis was performed to assess artifacts. Two physicians reported on defect presence or absence and their results were evaluated.
Different types of artifacts were characterized and their impact on defect detection was investigated.